12: JP Losman – 22nd overall to Bills in 2004:
The lesser-known Losman still stands as an infamous bust in NFL draft history after going in the first round of the talented 2004 draft. If you remember, this draft featured future Hall of Fame quarterbacks Ben Roethlisberger, Eli Manning, and Philip Rivers at the top of the first round. Towards the bottom of the first round, Buffalo decided to trade a first round pick, a second round pick, and a fifth-round pick to move back into the first round to select him.
He showed some flashes on the field, namely in the second half of the 2006 season. However, Losman flamed out after the 2008 season. He resurfaced with the Oakland Raiders in 2009, Seattle in 2010, and Miami in 2011, but never mounted any significant victories. There are worse on0field busts than Losman, but the sheer level of talent in the draft he was selected in and the price Buffalo paid to get him makes him a bust.
