10: Charles Rogers – 2nd overall to Lions in 2003:
Rogers may be the biggest wide receiver draft bust in NFL history. Selected 2nd overall in 2003 – one pick before legendary Houston Texans star Andre Johnson – Rogers had blazing speed and controversy to match. He showed flashes of greatness with three touchdowns in his first five games in 2003, but broke his collarbone and missed the rest of the year. He played only one game the following season before suffering the same injury and missing the rest of the year once again.
He was suspended for four games in 2005 for a violation of the NFL substance abuse policy, a punishment that led to him having to repay the Lions $8.5 million in bonuses they had already given him. He played only nine games in 2005, catching 14 passes for one touchdown. Despite workouts with New England, Tampa, and Miami before the 2006 season, Rogers never saw NFL action again. A colossal bust in every sense.