13: EJ Manuel – 16th overall to Bills in 2013:
Manuel’s NFL career was seemingly doomed from the start like many on this list. Fans and experts alike were left with their mouths wide open when the Bills used a first-round selection on the former Florida State QB in 2013.
His play on the field supported their surprise. Manuel’s rookie season was actually his best, as he completed 180 passes for 1,972 yards with 11 touchdowns and nine interceptions.
But it was all downhill from there, as Manuel failed to throw for more than five touchdowns in a single season the rest of his career. He finished his disappointing career with 343 completions for 3,767 yards, 20 touchdowns, and 16 interceptions. After four years with Buffalo, Manuel spent 2017 in Oakland, starting one game. He did resurface with Kansas City this year but retired from football on May 3.
