5. Jeff George – 1st overall to Colts in 1990:
The oft-criticized George actually had a solid enough NFL career with 2,298 completions for 27,602 yards, 154 touchdowns, and 113 interceptions over 12 years with five teams. Yet it was the sheer price the Indianapolis Colts paid to draft him in 1990 that makes him one of the biggest busts of all-time. They gave up a first rounder, Pro Bowl WR Andre Rison and elite tackle Chris Hinton for the rights to draft George.
He maintained only a 14-35 record with the Colts, making him one of the biggest busts of all-time considering the price they paid for him – and the fact they passed on three future NFL Hall of Famers to pick him up.
